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KMID : 0545120120220060800
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Journal of Microbiology and Biotechnology
2012 Volume.22 No. 6 p.800 ~ p.805
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Antimicrobial Activity of Licochalcone E Against Staphylococcus aureus and Its Impact on the Production of Staphylococcal Alpha-Toxin
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Tiezhong Zhou
Xuming Deng
Jiazhang Qiu
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Abstract
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Licochalcone E was firstly isolated from licorice root in 2005, which belongs to the retrochalcone family. Studies on the biological activities of licochalcone E were in the initial stage. In the study, we demonstrated that licochalcone E has potent antimicrobial property against Staphylococcus aureus. Furthermore, via hemolysis, Western blot, and real-time RT-PCR assays, we have shown that subinhibitory concentrations of licochalcone E dosedependently reduces the production of α-toxin in both methicillin-sensitive S. aureus (MSSA) and methicillinresistant S. aureus (MRSA). The data suggest that licochalcone E may deserve further investigation as a potential therapeutic against S. aureus infections, or the structure of licochalcone E may be used as a basis for chemical synthesis of novel anti-S. aureus compounds.
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KEYWORD
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Staphylococcus aureus, Licochalcone E, alpha-toxin
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